```html Tetrahedral Angular Frustration & Net Adaptive Work Simulator

Tetrahedral Frustration & Adaptive Work

109.47° sp3 scaffold vs. 104.45° polar water hinge (Δθ = 5.02° natural gap)

Liquid-Crystalline Spine
Peak Work W(Sopt) 11.42 at Sopt = 4.6
Viability Ceiling Smax 9.80 Exceeds 500 Da limit
Boundary Coupling μ 0.94 Compliant hydration
Frustration Factor Φ(Δθ) 0.99 Δθ = 5.0°
Net Adaptive Work Capacity W(S) vs. System Scale S S = 5.0 marks Lipinski 500 Da / span threshold
Bio-Tuned 109.5°/104.5° Liquid-Crystalline
Over-Rigid Planar sp2 (Δθ → 0.2°)
90° Orthogonal Uncoupled Baseline
5.0°
0.47
0.30
B-DNA Hydration Spine & Oral Drug Sweet Spot: The 5.02° mismatch prevents planar π-stacking crystallization while preserving directional H-bond torque across Lipinski's S = 5.0 barrier.
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